Two-year efficacy and safety of simvastatin 80 mg in familial hypercholesterolemia (the Examination of Probands and Relatives in Statin Studies With Familial Hypercholesterolemia [ExPRESS FH]).

نویسندگان

  • Pernette R W de Sauvage Nolting
  • Rudolf J A Buirma
  • Barbara A Hutten
  • John J P Kastelein
چکیده

Nature 1993;362:801–809. 5. Libby P, Egan D, Skarlatos S. Roles of infectious agents in atherosclerosis and restenosis: an assessment of the evidence and need for future research. Circulation 1997;96:4095–4103. 6. Saikku P, Leinonen M, Mattila K, Ekman MR, Nieminen MS, Makela PH, Huttunan JK, Valtonen V. Serological evidence of an association of a novel Chlamydia, TWAR, with chronic coronary artery disease and acute myocardial infarction. Lancet 1988;2:983–986. 7. Campbell LA, O’Brien ER, Cappuccio AL, Kuo CC, Wang S, Stewart D, Patton DL, Cummings PK, Graystone JT. Detection of Chlamydia pneumoniae (TWAR) in human coronary atherectomy tissues. J Infect Dis 1995;172:585–588. 8. Muhlestein JB, Hammond EH, Cariquist JF, Radicke E, Thomson MJ, Karagounis LA, Woods ML, Anderson JL. Increased incidence of Chlamydia species within the coronary arteries of patients with symptomatic atherosclerosis versus other forms of cardiovascular disease. J Am Coll Cardiol 1996;27:1555–1561. 9. Ramirez JA, The Chlamydia pneumoniae Atherosclerosis Study Group. Isolation of Chlamydia pneumoniae (TWAR) from the coronary arteries of a patient with coronary atherosclerosis. Ann Intern Med 1996;125:979–982. 10. Paterson DL, Hall J, Rasmussen SJ, Timms P. Failure to detect Chlamydia pneumoniae in atherosclerotic plaques of Australien patients. Pathology 1998; 30:169–172. 11. Ouchi K, Fujii B, Kudo S, Shirai M, Yamashita K, Gondo T, Ishihara T, Ito H, Nakazawa T. Chlamydia pneumoniae in atherosclerotic and nonatherosclerotic tissue. J Infect Dis 2000;181(suppl 3):441–443. 12. Bauriedel G, Welsch U, Likunga JA, Welz A, Luderitz B. Chlamydia pneumoniae in coronary plaques: increased detection with acute coronary syndrome. Dtsch Med Wochenschr 1999;124:375–380. 13. Juvonen J, Juvonen T, Laurila A, Alakarppa H, Lounatmaa K, Surcel HM, Leinonen Mkairalouma MI, Saikku P. Demonstration of Chlamydia pneumoniae in the walls of abdominal aortic aneurysms. J Vasc Surg 1997;25:499–505. 14. Wong YK, Dawkins KD, Ward ME. Circulating Chlamydia pneumoniae DNA as a predictor of coronary artery disease. J Am Coll Cardiol 1999;34:1435– 1439. 15. Maass M, Jurgen J, Gieffers J, Dalhoff K, Katus HA, Solbach W. Detection of Chlamydia pneumoniae within peripheral blood monocytes of patients with unstable angina or myocardial infarction. J Infect Dis 2000;181(suppl):S449–S451. 16. Wong YK, Dawkins KD, Ward ME. Circulating Chlamydia pneumoniae DNA as a predictor of coronary artery disease. J Am Coll Cardiol 1999;34:1435– 1439. 17. Nissen SF, Gurley JC. Assessments of coronary angioplasty results by intravascular ultrasound. In: Serruys PW, Strauss BH, King SB, eds. Restenosis After Intervention With New Mechanical Devices. Dordrecht, The Netherlands: Kluwer Academic, 1992:73–96. 18. Tiran A, Tio RA, Ossewaarde JM, Tiran B, den Heijer P, The TH, WildersTruschnig MM. Coronary angioplasty induces rise in Chlamydia pneumoniaespecific antibodies. J Clin Microbiol Inf Dis 1999;37:1013–1017. 19. Smieja M, Chong S, Natarajan M, Petrich A, Rainen L, Mahony JB. Circulating nucleic acids of Chlamydia pneumoniae and cytomegalovirus in patients undergoing coronary angiography. J Clin Microbiol 2001;39:596–600.

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Familial Hypercholesterolemia: From Diagnosis to Treatment

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A Novel Mutation in Exon 4 of the Low Density Lipoprotein (LDL) Receptor Gene in an Iranian Familial Hypercholesterolemia Patient

Familial hypercholesterolemia (FH) is an autosomal co-dominant disorder of lipid metabolism, caused by mutations in LDL receptor gene. The penetrance of FH is almost 100%, meaning that half of the offspring of affected parents born with disease. The patients are at risk of premature coronary heart disease (CHD). There is no report about the molecular basis of FH in Iran. Identification of mutat...

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Efficacy and safety of ezetimibe coadministered with atorvastatin or simvastatin in patients with homozygous familial hypercholesterolemia.

BACKGROUND Patients with homozygous familial hypercholesterolemia (HoFH) have a high incidence of cardiovascular morbidity and mortality from premature atherosclerosis, and the efficacy of pharmacological therapy has been limited. We evaluated the efficacy, safety, and tolerability of ezetimibe, a novel cholesterol absorption inhibitor, in a multicenter, double-blind, randomized trial of HoFH p...

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Familial hypercholesterolemia: A case report

Familial hypercholesterolemia (FH) is a hereditary dislipidemia. Patients present with extremely high level of low-density lipoprotein cholesterol (LDL-C), which is due to mutation in the gene of LDL receptor. Homozygous patients (HoFH) whose incidence is 1 in 1.000.000 are at high risk of premature aortic valve stenosis, and coronary artery atherosclerosis. In homozygous individuals cardiov...

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Molecular Diagnosis of Familial Hypercholesterolemia

Abstract Background and objectives: Familial hypercholesterolemia (FH) is an autosomal disorder characterized by increased levels of total cholesterol and low density lipoprotein cholesterol. The FH clinical phenotype has been associated with increased risk of coronary heart disease and premature death. The mutation in LDLR gene in most cases is responsible for FH phenotype. Furthermore, other ...

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عنوان ژورنال:
  • The American journal of cardiology

دوره 90 2  شماره 

صفحات  -

تاریخ انتشار 2002